The blood schizontocidal action of erythromycin against Plasmodium knowlesi infections in Macaca mulatta

Chloroquine-induced pigment clumping (CIPC) in vitro in Plasmodium knowlesi is inhibited by 7.3 micrograms ml-1 erythromycin. P. knowlesi infections in rhesus monkeys were controlled by doses of erythromycin which gave similar serum levels of the antibiotic. The antimalarial effect was complete but temporary, and recrudescences were noted.