Effect of parathyroidectomy on Sodium metabolism in DOCA-NaCl treated and spontaneously hypertensive rats

Parathyroidectomy (PTX) lessens hypertension if performed on young SHR, and on Sprague-Dawley rats, one week before DOCA + NaCl treatment. PTX also increases diuresis and possibly sodium excretion. In this work, sodium balance was investigated during the onset of hypertension, since in SHR and DOCA + NaCl rats, sodium metabolism is related to the level of hypertension. Results show that sodium excretion is enhanced in PTX-DOCA rats immediately after DOCA treatment but lowered in PTX-SHR for 11 weeks. Nevertheless after PTX, sodium balance remains unchanged throughout the experiment. It appears that PTX does not lessen hypertensive development in both models via a decreased sodium balance.