A comparison of diclofensine and desmethylimipramine using tyramine pressor tests in normal subjects

Eight male volunteers received placebo, diclofensine 25 mg, diclofensine 50 mg and desmethylimipramine (DMI) 50 mg at least a week apart. Using tyramine pressor tests, no statistically significant differences between the noradrenaline reuptake blocking effects of the three active treatments could be demonstrated. Visual analogue rating scales showed an increase in dryness of the mouth at 3 h after DMI but no similar effect after either dose of diclofensine.