[Effect of antioxidants on the release of 3H-serotonin by rat brain synaptosomes]

The effects of free radical scavengers of different chemical structure (hydroxypyridines, hindered phenols, hydroxyphenothiazines) on processes of 3H-hydroxytryptamine uptake and release by rat brain synaptosomes were studied. All free radical scavengers used inhibited 3T-hydroxytryptamine uptake and stimulated 3H-hydroxytryptamine release, with the efficacy being reduced in the following order: 7-hydroxyaminazine greater than butylated hydroxytoluene greater than paginol-2-methyl-6-ethyl-3-hydroxypyridine greater than alpha-tocopherol. The effects of free radical scavengers were eliminated in the presence of EGTA or after cooling to 4 degrees C.