Radiocolloid redistribution and multiple splenic infarcts in myelofibrosis

A 66-year-old man has myelofibrosis with radiocolloid demonstrated splenomegaly and shift of activity to the sudden spleen. Four months later, he experienced sudden left-sided paid. A repeat radiocolloid study showed a marked change. The spleen was represented by only a few functional areas with several photopenic regions. Radioactivity was now principally present in the liver, with considerable uptake in the vertebral marrow and lungs. The splenic lesions were multiple acute infarcts. Sudden loss of the spleen's ability to extract radiocolloid was likely, followed by utilization of reticuloendothelial cells in the liver, bone marrow and lungs.