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Related Experiment Videos

Delayed cutaneous hypersensitivity response in patients receiving nutritional support.

R E Griffin, C D Champagne, B R Bistrian

    Clinical Pharmacy
    |September 1, 1983
    PubMed
    Summary

    Aggressive nutritional therapy can restore immune responses in hospitalized patients. Skin tests using Candida and mumps antigens effectively detected anergy and immune function.

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    Area of Science:

    • Immunology
    • Clinical Nutrition

    Background:

    • Hospitalized patients often experience impaired cellular immunity, a condition known as anergy.
    • Nutritional status significantly impacts immune function.
    • Assessing cellular immunity is crucial for managing critically ill patients.

    Purpose of the Study:

    • To evaluate the sensitivity and specificity of skin-test antigens for assessing cellular immunity.
    • To determine the prevalence of anergy in hospitalized patients undergoing nutritional therapy.
    • To investigate the impact of aggressive nutritional support on immune responses.

    Main Methods:

    • 195 hospitalized patients were tested for delayed cutaneous hypersensitivity using Candida albicans, mumps, streptokinase/streptodornase, and tetanus toxoid antigens.
    • Some patients underwent repeat skin testing at two-week intervals during nutritional support.

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  • Immune responses were assessed by measuring positive reactions to skin-test antigens.

    • Main Results:

    • 92.8% of patients initially responded to at least one antigen.
    • Candida and mumps skin tests showed the highest response rates (80% and 75%, respectively).
    • Concurrent use of Candida and mumps antigens yielded a 92.3% response rate, and repeat testing often converted anergic patients to responders.

    Conclusions:

    • Candida and mumps skin tests are effective in detecting anergy.
    • Aggressive nutritional support can maintain and restore cellular immune responses in hospitalized patients.
    • Skin testing for delayed cutaneous hypersensitivity is a valuable tool in assessing immune status during nutritional therapy.