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Pituitary coma with continuing menstruation.

D M Mitchell, S C Webb, B I Hoffbrand

    Postgraduate Medical Journal
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

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    Pituitary coma is rare, even with ongoing menstruation. This case highlights that recent menstrual periods do not rule out advanced hypopituitarism in severe hyponatremia diagnosis.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine

    Background:

    • Pituitary coma, a critical manifestation of hypopituitarism, typically presents with hormonal deficiencies.
    • Menstrual irregularities or amenorrhea are common in women with hypopituitarism due to hormonal imbalances.

    Observation:

    • This report details an exceptionally rare case of pituitary coma occurring in a woman with a history of continuing menstruation.
    • The patient presented with severe hyponatremia, a common electrolyte disturbance in hypopituitarism.

    Findings:

    • The presence of recent menstrual periods was initially considered to potentially exclude severe hypopituitarism.
    • Despite ongoing menstruation, the clinical presentation and diagnostic workup confirmed advanced hypopituitarism as the cause of pituitary coma and severe hyponatremia.

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    Implications:

    • This case underscores the importance of considering hypopituitarism in the differential diagnosis of severe hyponatremia, regardless of menstrual status.
    • Physicians should maintain a high index of suspicion for pituitary coma in patients with severe hyponatremia, even in the presence of seemingly contradictory symptoms like regular menstruation.