Effects of daily 30 mcg d-norgestrel on growth hormone and cortisol

The effects of d-norgestrel on serum growth hormone and cortisol were determined in 9 healthy Thai women, who took 30 mcg d-norgestrel tablet daily for 12 months. Growth hormone (both fasting and during OGTT) and morning cortisol concentrations were measured before and after 6 and 12 months. It was found that growth hormone concentrations tended to decrease but were not statistically significant. Patterns of growth hormone in relation to glucose and insulin measured during OGTT were similar throughout the study. The morning cortisol values slightly increased after treatment. The limited data from this study suggested that d-norgestrel, at the daily dose of 30 mcg, did not significantly alter serum growth hormone and cortisol levels in the group of Thai women after one year's time of use.