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Subchronic inhalation toxicity of 1,3,5-trichlorobenzene
Drug and Chemical Toxicology
|January 1, 1983
Summary
Exposure to 1,3,5-trichlorobenzene vapors in rats showed no blood or clinical chemistry changes. High-dose exposure caused nasal passage respiratory tissue changes and facial irritation in rats.
Area of Science:
- Toxicology
- Environmental Health
- Inhalation Toxicology
Background:
- 1,3,5-trichlorobenzene is an industrial chemical.
- Understanding its toxicological profile is crucial for risk assessment.
Purpose of the Study:
- To evaluate the effects of subchronic inhalation exposure to 1,3,5-trichlorobenzene in rats.
- To identify potential target organs and dose-response relationships.
Main Methods:
- Rats were exposed to 0, 10, 100, or 1000 mg/m³ of 1,3,5-trichlorobenzene vapors.
- Exposure duration was 6 hours/day, 5 days/week, for up to 13 weeks.
- Hematology, clinical chemistry, organ weights, and histopathology were assessed.
Main Results:
- No significant treatment-related changes were observed in blood parameters or clinical chemistry.
- Squamous metaplasia and hyperplasia were noted in the nasal respiratory epithelium of high-dose rats.
- Increased incidence of dried red material on the faces of high-dose rats was observed.
Conclusions:
- Subchronic inhalation of 1,3,5-trichlorobenzene primarily affects the nasal respiratory epithelium in rats at high concentrations.
- Systemic toxicity was not evident at the tested dose levels.
- Nasal irritation and tissue changes are key findings for 1,3,5-trichlorobenzene exposure.