Norfenefrine: haemodynamic effects in healthy volunteers at rest and during orthostasis

The haemodynamic effects of the alpha-mimetic norfenefrine 1.5-4.5 micrograms/kg/min i.v. were studied by invasive methods in six healthy male volunteers at rest and during orthostasis (90 degrees on tilt table). Norfenefrine was more effective at rest and during exercise in raising blood pressure in the pulmonary than in the systemic arterial system. It was concluded that norfenefrine should be effective in the treatment of patients with orthostatic dysregulation due to reduced venous tone.