Acantholytic dyskeratosis on both legs

Area of Science:

• Dermatology
• Histopathology

Background:

• Persistent acantholytic dermatosis is a rare skin condition.
• Atypical presentations can pose diagnostic challenges.

Observation:

• A 33-year-old woman presented with an 8-year history of pruritic, brownish-red keratotic papules on both legs.
• The lesions exhibited an unusual distribution, primarily affecting the lower extremities.

Findings:

• Histopathological examination of a biopsy specimen revealed key features of acantholysis.
• Benign dyskeratosis was also noted, supporting the diagnosis of acantholytic dermatosis.

Implications:

• This case highlights the importance of considering persistent acantholytic dermatosis even with atypical lesion distribution.
• Further research may elucidate the specific factors contributing to unusual presentations of this dermatosis.