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Related Experiment Videos

Sympathetic nerve failure in diabetes.

P J Watkins, M E Edmonds

    Diabetologia
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic neuropathy often involves sympathetic nervous system damage, leading to vascular issues like reduced blood flow and edema. New treatments, such as ephedrine, show promise in managing these complications.

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    Area of Science:

    • Neurology
    • Vascular Medicine
    • Diabetology

    Background:

    • Diabetic neuropathy is frequently associated with sympathetic nervous system damage.
    • This sympathetic damage may underlie various vascular complications, including postural hypotension and increased peripheral blood flow.
    • Structural changes like medial smooth muscle degeneration and calcification are observed in diabetic neuropathy, likely due to sympathetic denervation.

    Purpose of the Study:

    • To highlight the significance of sympathetic damage in diabetic neuropathy.
    • To explore the link between sympathetic dysfunction and vascular abnormalities in the neuropathic foot.
    • To discuss potential therapeutic strategies targeting sympathetic defects.

    Main Methods:

    • The study reviews existing literature and clinical observations regarding sympathetic damage in diabetic neuropathy.

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  • It analyzes the functional consequences of sympathetic denervation on vasomotor control and peripheral circulation.
  • Pathological changes in blood vessels and bone are correlated with autonomic dysfunction.

    • Main Results:

    • Sympathetic damage is a common but underestimated feature of diabetic neuropathy.
    • Loss of vasomotor control contributes to postural hypotension, increased peripheral blood flow, and arteriovenous shunting.
    • Consequences include bone demineralization, joint destruction, intractable edema, and painful neuropathies.
    • Sympathomimetic agents, like ephedrine, demonstrate efficacy in treating neuropathic edema.

    Conclusions:

    • Sympathetic nervous system dysfunction plays a critical role in the pathogenesis of diabetic neuropathy's vascular and structural complications.
    • Understanding these autonomic defects opens avenues for novel therapeutic interventions.
    • Ephedrine shows potential as a treatment for neuropathic edema, suggesting a broader role for sympathomimetic agents.