Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Model systems and their predictive value in assessing teratogens.

R Hill

    Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long Amplicon Nanopore Sequencing for Dual-Typing RdRp and VP1 Genes of Norovirus Genogroups I and II in Wastewater.

    Food and environmental virology·2024
    Same author

    New and Interesting Fungi. 7.

    Fungal systematics and evolution·2024
    Same author

    Cold indoor temperatures and their association with health and well-being: a systematic literature review.

    Public health·2023
    Same author

    Quantifying the Representation of Black Adolescents in Suicide Intervention Research.

    Research on child and adolescent psychopathology·2023
    Same author

    Fungal Planet description sheets: 1284-1382.

    Persoonia·2023
    Same author

    14-3-3 and Smad2/3 are crucial mediators of atypical-PKCs: Implications for neuroblastoma progression.

    Frontiers in oncology·2023
    Same journal

    Characterization of the effects of musk ketone on mouse hepatic cytochrome P450 enzymes.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
    Same journal

    Tetracycline-induced steatosis in primary canine hepatocyte cultures.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
    Same journal

    Tributyl phosphate effects on urine and bladder epithelium in male Sprague-Dawley rats.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
    Same journal

    Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
    Same journal

    Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
    Same journal

    Intratracheal inhalation vs intratracheal instillation: differences in particle effects.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
    See all related articles

    Preclinical animal toxicity studies are crucial for drug safety evaluation. However, current animal models show limited predictability for human teratogenic responses, necessitating further research into mechanisms and species differences.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Developmental Biology

    Background:

    • Drug safety evaluation relies on preclinical animal toxicity studies for ethical and regulatory compliance.
    • Historically, specific teratogenicity testing lacked standardization until the thalidomide tragedy prompted regulatory inclusion.
    • Current animal models for teratogenicity assessment exhibit limitations in predicting human outcomes.

    Purpose of the Study:

    • To review the evolution and current status of preclinical teratogenicity testing in drug development.
    • To highlight the challenges and limitations in predicting human teratogenic risk from animal studies.
    • To emphasize the need for understanding the mechanisms of teratogenesis and species-specific responses.

    Main Methods:

    • Review of historical regulatory guidelines and scientific literature on teratogenicity testing.

    Related Experiment Videos

  • Analysis of species differences in drug response and developmental processes.
  • Discussion of the predictive value of animal models in human risk assessment.

    • Main Results:

    • Teratogenicity studies became a regulatory requirement globally after the 1960s.
    • Significant discrepancies exist between animal model results and human teratogenic outcomes.
    • The predictability of animal tests for human safety remains a significant concern.

    Conclusions:

    • Understanding the molecular mechanisms of teratogenesis is key to improving predictive accuracy.
    • Addressing species differences in drug metabolism and developmental pathways is essential.
    • Enhanced confidence in animal study predictions requires deeper mechanistic insights.