Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemodynamic response: decrease in cardiac output vs reduction in vascular resistance.

P Lund-Johansen

    Hypertension (Dallas, Tex. : 1979)
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparative haemodynamic effects of labetalol, timolol, prazosin and the combination of tolamolol and prazosin.

    British journal of clinical pharmacology·2015
    Same author

    [Are newer antihypertensive agents better than the older ones? Results of trials (CAPPP, STOP-2, NORDIL, INSIGHT and ALLHAT) with newer antihypertensive agents].

    Ugeskrift for laeger·2002
    Same author

    [Comparison of preventive effect of "new" and "old" antihypertensive agents].

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2001
    Same author

    Long-term central hemodynamic effects at rest and during exercise of losartan in essential hypertension.

    American heart journal·2000
    Same author

    Randomised trial of effects of calcium antagonists compared with diuretics and beta-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study.

    Lancet (London, England)·2000
    Same author

    Similar central hemodynamics in salt-sensitive and salt-resistant hypertensive patients.

    Blood pressure·2000
    Same journal

    Brain Iron in Nucleus Accumbens and Cognitive Function in Preeclampsia.

    Hypertension (Dallas, Tex. : 1979)·2026
    Same journal

    Hypertension Treatment Intentions: A Health Belief Model Analysis.

    Hypertension (Dallas, Tex. : 1979)·2026
    Same journal

    Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO.

    Hypertension (Dallas, Tex. : 1979)·2026
    Same journal

    Longitudinal Maternal IgG and IgA Glycosylation Profiles in Pregnancy Reveal Early Immune Alterations in Placenta-Related Complications: The Rotterdam Periconception Cohort.

    Hypertension (Dallas, Tex. : 1979)·2026
    Same journal

    Blood Pressure Variability and Outcomes Across Antihypertensive Regimens.

    Hypertension (Dallas, Tex. : 1979)·2026
    Same journal

    Rural Health and Health Disparities in Hypertension Management: A Scientific Statement From the American Heart Association.

    Hypertension (Dallas, Tex. : 1979)·2026
    See all related articles

    Antihypertensive drugs impact hemodynamics differently. Prazosin normalized cardiac output and total peripheral resistance, while beta-blockers reduced cardiac output without lowering total peripheral resistance. Understanding these effects is key for essential hypertension treatment.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Essential hypertension is characterized by increased total peripheral resistance (TPR) and normal or reduced cardiac output (CO).
    • Untreated hypertension leads to progressive increases in TPR and mean arterial pressure (MAP), with decreases in CO and stroke volume (SV) over time.

    Purpose of the Study:

    • To evaluate the hemodynamic responses to chronic antihypertensive drug therapy at rest and during exercise in men with mild to moderate essential hypertension.
    • To compare the effects of different drug classes on total peripheral resistance, cardiac output, and stroke volume.

    Main Methods:

    • Hemodynamic parameters were assessed at rest and during exercise in 250 men with WHO Stage I essential hypertension undergoing chronic drug therapy.
    • Drug classes studied included thiazide diuretics, nifedipine, verapamil, prazosin, beta-blockers, and captopril.

    Related Experiment Videos

    Main Results:

    • Thiazide diuretics, nifedipine, and verapamil reduced TPR but did not increase subnormal CO or SV.
    • Prazosin significantly reduced TPR and increased CO and SV, especially during exercise.
    • Beta-blockers chronically reduced CO and heart rate (HR) without decreasing TPR, leading to an increased arteriovenous oxygen difference.
    • Captopril reduced TPR and CO in patients with therapy-resistant hypertension.
    • Five-year beta-blocker therapy maintained blood pressure control but did not further decrease TPR.

    Conclusions:

    • Different antihypertensive medications have distinct hemodynamic profiles.
    • Prazosin offers superior normalization of central hemodynamics compared to other agents studied.
    • Beta-blockers may not be optimal for improving underlying hemodynamic disturbances in hypertension.