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Toxic epidermal necrolysis. Case report.

G Anhalt, C F Snelling

    Plastic and Reconstructive Surgery
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Toxic epidermal necrolysis (TEN), a severe skin reaction, can be triggered by trimethoprim and sulfamethoxazole. Burn surgeons should manage TEN due to its similarity to burn injuries and positive response to similar treatments.

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    Area of Science:

    • Dermatology
    • Pharmacology
    • Surgery

    Background:

    • Toxic epidermal necrolysis (TEN) is a rare but life-threatening mucocutaneous reaction.
    • Trimethoprim-sulfamethoxazole is a commonly prescribed antibiotic combination.
    • Understanding drug-induced skin reactions is crucial for patient safety.

    Observation:

    • A case report details a patient who developed TEN.
    • The patient's TEN was associated with trimethoprim-sulfamethoxazole therapy.
    • The skin manifestations resembled extensive partial-thickness burns.

    Findings:

    • TEN shares clinical similarities with severe burn injuries.
    • The patient showed a favorable response to treatments typically used for burns.
    • Early recognition and intervention are key in managing TEN.

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    Implications:

    • Burn surgeons possess relevant expertise for managing TEN.
    • Multidisciplinary collaboration can improve outcomes for TEN patients.
    • Awareness of TEN's presentation and treatment parallels is essential for surgical teams.