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Systemic lupus erythematosus and diffuse soft tissue calcifications.

S Carette, M B Urowitz

    International Journal of Dermatology
    |September 1, 1983
    PubMed
    Summary
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    Systemic lupus erythematosus (SLE) can lead to severe complications like soft tissue calcification and avascular necrosis, particularly with corticosteroid use. This case highlights significant adverse effects, including muscle weakness and skin lesions, emphasizing careful monitoring during treatment.

    Area of Science:

    • Dermatology
    • Rheumatology
    • Endocrinology

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
    • Corticosteroids are commonly used to manage SLE but can have significant side effects.

    Observation:

    • A 26-year-old woman with SLE presented with extensive soft tissue calcification.
    • She experienced proximal muscle weakness and avascular necrosis, complications linked to corticosteroid therapy.
    • Skin examination revealed erythematosus induration and yellowish papules on her legs.

    Findings:

    • Biopsies showed dermal thickening with collagen deposition and calcium deposits in indurated areas.
    • Subcutaneous fat biopsies revealed eosinophilic degeneration.
    • These findings indicate severe cutaneous and soft tissue manifestations of SLE and its treatment.

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    Implications:

    • This case underscores the potential for severe complications from corticosteroid treatment in SLE patients.
    • It highlights the importance of recognizing and managing both systemic and cutaneous manifestations.
    • Further research into managing corticosteroid-induced complications in autoimmune diseases is warranted.