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Macrophage activation with ubiquinones and their related compounds in mice

I Saiki, Y Tokushima, K Nishimura

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition

|January 1, 1983

Abstract:

The effect of ubiquinones (Q-2, -7 and -10) and their related compounds (QSA-1, -4, -6, -10 and -18) on macrophage functions was investigated. All compounds tested in this study, except QSA-4 and -6, augmented macrophage-mediated functions such as cytolysis, cytostasis and H2O2 release. Furthermore, QSA-10 and QSA-10(H2) were also shown to increase antibody-dependent cell-mediated cytotoxicity. However, QSA-10(Phenol), which lacks a quinone ring, was not observed these activities. It was suggested that quinone ring might be important for the expression of macrophage activation.

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