Effect of hyperosmolar peritoneal dialysis fluid on the elimination of small- and medium-molecular substances

The efficiency of peritoneal dialysis by the use of hyperosmolar dialyzing fluid (680 mOsm/1) was studied in 7 patients with chronic renal failure. The results were referred to the control values obtained in the first and in the terminal periods. In the course of treatment by means of the solution of high osmolarity the clearance of small- and medium-molecular substances increased. A significant increase in ultrafiltration was demonstrable. Protein loss and elevation of the blood glucose levels were noted as side-effects.