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Biologic markers and antidepressant response.

D G Ostrow, A Okonek, R Gibbons

    The Journal of Clinical Psychiatry
    |September 1, 1983
    PubMed
    Summary
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    Biologic markers can help predict antidepressant treatment response, guiding personalized medicine. This research reviews potential markers for selecting optimal antidepressant therapies, including psychological treatments.

    Area of Science:

    • Psychiatry and Neurobiology
    • Pharmacogenomics
    • Clinical Psychology

    Background:

    • Antidepressant treatment selection is often empirical.
    • Predicting individual patient response is a significant clinical challenge.
    • Biologic markers offer a potential solution for personalized antidepressant therapy.

    Purpose of the Study:

    • To review biologic markers for predicting antidepressant treatment response.
    • To explore the potential of these markers in guiding drug selection for individual patients.
    • To consider the utility of markers for predicting response to psychological or combined treatments.

    Main Methods:

    • Literature review of current research on biologic markers.
    • Analysis of studies investigating the predictive validity of various biomarkers.

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  • Synthesis of findings related to predicting response to pharmacologic and psychologic interventions.

    • Main Results:

    • Several biologic markers are under development as predictors of antidepressant response.
    • These markers show promise in moving towards a more rational selection of antidepressant drugs.
    • The predictive utility may extend beyond drug treatments to psychological therapies.

    Conclusions:

    • Biologic markers are crucial for advancing personalized antidepressant treatment.
    • Further research is needed to validate and implement these markers in clinical practice.
    • Personalized approaches incorporating biologic markers can optimize outcomes for depression.