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Generalized pruritus and systemic disease.

G R Kantor, D P Lookingbill

Journal of the American Academy of Dermatology

|September 1, 1983

Summary

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Generalized pruritus (GP) patients show a higher incidence of systemic disease compared to psoriasis controls. This suggests a link between systemic conditions and persistent itching, warranting further investigation.

Area of Science:

Dermatology
Internal Medicine
Clinical Research

Background:

Generalized pruritus (GP) is a common dermatological symptom.
Systemic diseases are often associated with generalized pruritus.
Understanding the link between GP and systemic illness is crucial for diagnosis and management.

Observation:

A retrospective study compared 44 generalized pruritus cases with 44 age- and sex-matched psoriatic controls.
Systemic diseases were identified in 30% of GP cases versus 23% of psoriasis controls.
Excluding hypothyroidism and diabetes mellitus, 18% of GP patients had associated systemic disease compared to 2% of psoriasis patients (p<0.02).

Findings:

A statistically significant association was found between generalized pruritus and systemic diseases.

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A temporal relationship between systemic disease and GP was suggested in 14% of cases.

Persistent itching was reported in 66% of GP patients, with a mean duration of 57.7 months.

Implications:

The findings suggest that generalized pruritus may indicate an underlying systemic condition.
Recommendations for outpatient workup of GP are provided.
Further research is needed to elucidate the causal relationship and improve management strategies for persistent pruritus.