Quantitative assessment of the effect of some excipients on nitrazepam stability in binary powder mixtures

The decomposition rate constants, normalized for dilution and relative specific surface effects. Of nitrazepam in simple binary powder mixtures with talcum, lactose-H2O, microcrystalline cellulose, corn starch, mannitol, and saccharose are shown to be linearly related to the nitrogen adsorption energy of the excipients.