Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyaluronic acid double helix.

S Arnott, A K Mitra, S Raghunathan

    Journal of Molecular Biology
    |October 5, 1983
    PubMed
    Summary

    Hyaluronic acid likely forms a double helix with extensive hydrogen bonds, explaining its unique viscoelastic properties. This structure involves carboxylate interactions and water bridges, differing from previous models.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    First Constraints on the Epoch of Reionization Using the Non-Gaussianity of the Kinematic Sunyaev-Zel'dovich Effect from the South Pole Telescope and Herschel-SPIRE Observations.

    Physical review letters·2024
    Same author

    Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis.

    Cell reports·2023
    Same author

    Treatment of glioblastoma using multicomponent silica nanoparticles.

    Advanced therapeutics·2020
    Same author

    Detection of CMB-Cluster Lensing using Polarization Data from SPTpol.

    Physical review letters·2019
    Same author

    Target highlights in CASP13: Experimental target structures through the eyes of their authors.

    Proteins·2019
    Same author

    Delivery of drugs into brain tumors using multicomponent silica nanoparticles.

    Nanoscale·2019

    Area of Science:

    • Biochemistry
    • Polymer Science
    • Materials Science

    Background:

    • Hyaluronic acid is a crucial glycosaminoglycan with significant biological and industrial applications.
    • Its unique viscoelastic properties are well-known but not fully understood at a molecular level.
    • Previous models of hyaluronic acid structure may not fully capture its complex interactions.

    Purpose of the Study:

    • To propose a revised structural model for the hyaluronic acid double helix.
    • To elucidate the molecular interactions responsible for hyaluronic acid's viscoelasticity.
    • To reconcile structural hypotheses with observed solution properties.

    Main Methods:

    • Analysis of existing structural data and biophysical principles.
    • Molecular modeling and simulation (implied).
    • Interpretation of hydrogen bonding networks and water-mediated interactions.

    Main Results:

    • The hyaluronic acid double helix likely features extensively hydrogen-bonded chains.
    • Carboxyl-carboxylate hydrogen bonds and water bridges are key stabilizing interactions.
    • Transient double-helical loop formation contributes to viscoelasticity.

    Conclusions:

    • A revised double-helix model for hyaluronic acid is proposed, emphasizing hydrogen bonding.
    • The molecular structure directly explains the characteristic viscoelastic behavior of hyaluronic acid solutions.
    • This finding advances our understanding of polysaccharide structure-function relationships.

    Related Experiment Videos