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Comparative developmental toxicity of triethyltin using split-litter and whole-litter dosing
Journal of Toxicology and Environmental Health
|July 1, 1983
Summary
Triethyltin (TET) developmental toxicity was examined using split-litter and whole-litter models. The dosing regimen did not significantly alter toxicity outcomes, suggesting it is not the primary determinant of TET
Area of Science:
- Neuroscience
- Developmental Toxicology
- Environmental Health
Background:
- Previous studies indicated littermate treatment conditions influence triethyltin (TET) toxicity.
- Acute postnatal exposure to neurotoxicants can cause lasting developmental effects.
Purpose of the Study:
- To compare developmental toxicity of triethyltin (TET) using split-litter versus whole-litter dosing models.
- To determine if the dosing regimen influences TET-induced developmental toxicity.
Main Methods:
- Two dosing models were employed: split-litter (pup treated, littermates untreated) and whole-litter (all pups treated).
- Pups received single doses of 0, 3, 6, or 9 mg TET/kg on postnatal day 5.
- Outcomes assessed included preweaning body weight, mortality, brain weight, postweaning body weight, and adult figure-eight maze activity.
Main Results:
- Preweaning body weight reductions were more persistent in the split-litter group at 3 mg/kg TET.
- Adult figure-eight maze activity increased in 6 and 9 mg/kg TET groups, with a greater effect in the split-litter group at 9 mg/kg.
- Mortality (approx. 50% at 9 mg/kg), brain weight, and postweaning body weight showed no significant differences between dosing models.
Conclusions:
- Developmental toxicity induced by triethyltin (TET) is not primarily determined by the dosing regimen.
- The split-litter model revealed subtle differences in growth and activity, but overall toxicity patterns were similar.
- These findings contribute to understanding neurotoxicant exposure and developmental outcomes.