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Related Experiment Videos

Unknown primary melanoma.

J M Klausner, M Gutman, M Inbar

    Journal of Surgical Oncology
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Unknown primary melanoma, while rare, has a prognosis similar to typical melanoma. Aggressive surgical treatment for regional lymph node metastasis shows promising long-term survival for some patients.

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    Area of Science:

    • Oncology
    • Dermatology
    • Surgical Pathology

    Background:

    • Melanoma of unknown primary (MUP) is a rare clinical presentation.
    • Identifying MUP is crucial for appropriate staging and treatment.

    Purpose of the Study:

    • To evaluate the clinical characteristics and outcomes of patients with unknown primary melanoma.
    • To assess the efficacy of aggressive surgical management for MUP.

    Main Methods:

    • Retrospective review of 230 melanoma patients over 8 years.
    • Analysis of 12 patients diagnosed with unknown primary melanoma.
    • Surgical management (lymphadenectomy) followed by adjuvant therapy for regional lymph node metastasis.

    Main Results:

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  • 5.2% of melanoma patients had unknown primary lesions.
  • Nine patients presented with regional lymph node metastasis, one with parotid gland involvement, and two with disseminated disease.
  • Four patients with single lymph node metastasis remain disease-free 4-6 years post-treatment.
  • One patient with multiple groin metastases survived 8 years post-surgery.
  • Five patients with multiple regional lymph node metastases died within 16 months to 3 years.
  • Both patients with disseminated MUP died within one month.

    • Conclusions:

    • Unknown primary melanoma prognosis appears comparable to melanoma of known primary at similar stages.
    • Aggressive surgical intervention, including lymphadenectomy, is warranted for MUP with regional lymph node metastasis.
    • Further research into optimal adjuvant therapies for MUP is indicated.