Related Experiment Video

Updated: Aug 9, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences

A P Minton

    Molecular and Cellular Biochemistry
    |January 1, 1983
    PubMed

    More Related Videos

    Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen08:13

    Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen

    Published on: March 4, 2017

    Single-Molecule Measurement of Protein Interaction Dynamics Within Biomolecular Condensates06:48

    Single-Molecule Measurement of Protein Interaction Dynamics Within Biomolecular Condensates

    Published on: January 5, 2024

    Related Concept Videos

    Protein Denaturation01:28

    Protein Denaturation

    The function of proteins depends on their native three-dimensional structure, which is dictated by the amino acid sequence of the specific protein. Folding of the polypeptide chain takes place under specific conditions that energetically favor the folded conformation. In contrast, protein denaturation occurs spontaneously under unfavorable conditions that disrupt the integrity of the folded conformation. Thus, the chemical and physical environment of a protein, such as significant changes in pH...
    Quantitative Aspects of Drug-Receptor Interaction01:30

    Quantitative Aspects of Drug-Receptor Interaction

    The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower Kd...
    Thermodynamics: Chemical Potential and Activity01:10

    Thermodynamics: Chemical Potential and Activity

    The effective concentration of a species in a solution can be expressed precisely in terms of its activity. Activity considers the effect of electrolytes present in the vicinity of the species of interest and depends on the ionic strength of the solution. The activity of a species is expressed as the product of molar concentration and the activity coefficient of the species.
    The thermodynamic equilibrium constant is more accurately defined in terms of activity rather than concentration.
    Thermodynamics: Activity Coefficient01:24

    Thermodynamics: Activity Coefficient

    Activity is the measure of the effective concentration of the species in solution. It can be expressed as the product of the molar concentration of the species and its activity coefficient. The activity coefficient is a dimensionless quantity and depends on the total ionic strength of the solution.
    The activity coefficient is a measure of the deviation from ideal behavior. When the ionic strength of the solution is minimal, the activity coefficient of an ionic species is close to unity, making...
    Chemical Equilibria: Redefining Equilibrium Constant01:20

    Chemical Equilibria: Redefining Equilibrium Constant

    The effect of an inert salt on the solubility of a sparingly soluble salt is known as the salt effect. The degree of the salt effect varies with the ionic strength of the solution, which in turn depends on the activity of the species in the solution. The activity is expressed as the product of concentration and the activity coefficient of the species.
    To calculate the equilibrium constants of solutions of moderately high ionic strength, one must account for the salt effect. This redefined...
    Factors Affecting Activity Coefficient01:17

    Factors Affecting Activity Coefficient

    The extended Debye-Hückel equation indicates that the activity coefficient of an ion in an aqueous solution at 25°C depends on three partially interdependent properties: the ionic strength of the solution, the charge of the ion, and the ion size. 
    The activity coefficient value for an ion is close to one when the solution has almost zero ionic strength, i.e., when the solution shows close to ideal behavior. As the ionic strength of the solution increases from 0 to 0.1 mol/L, a decrease in the...