Does DDAVP (1-desamino-8-D-arginine-vasopressin) cross the blood-CSF barrier?

Plasma and CSF 1-desamino-8-D-arginine-vasopressin (DDAVP) levels were measured by radioimmunoassay following the infusion at constant rates of various amounts of DDAVP (12.5-20 ng/kg/min) into the jugular veins of 4 adult sheep prepared with chronic, indwelling cisterna magnum catheters, as well as jugular vein and carotid artery catheters. The mean steady-state CSF DDAVP concentration did not vary significantly from zero. Thus, DDAVP does not cross the blood-CSF barrier when administered intravenously.