Aberrant retinotectal projection induced by larval unilateral enucleation in Xenopus

The left eye was removed at late larval stages in Xenopus and the optic fibre projections of the remaining right eye assessed from 2 weeks to 13 months past metamorphosis. [3H]Proline autoradiography and electrophysiological recording of the visual field projection showed an aberrant optic fibre projection from the peripheral ventral retina to the right ipsilateral tectum. It is suggested that optic fibres, arising from the retina formed after the time of the operation, reach the ipsilateral tectum by following the axon debris of the removed eye.