Related Experiment Videos
Ethanol-induced hyperglycemia mediated by the central nervous system
Pharmacology, Biochemistry, and Behavior
|January 1, 1983
Summary
Two mouse lines show different responses to ethanol-induced hyperglycemia, with LS/Ibg mice being more sensitive. This effect is controlled by the central nervous system and influenced by adrenergic pathways.
Area of Science:
- Neuroscience
- Endocrinology
- Pharmacology
Background:
- Differential sensitivity to ethanol exists between mouse lines.
- Ethanol affects blood glucose levels, a phenomenon requiring further investigation.
Purpose of the Study:
- To investigate the central nervous system's role in ethanol-induced hyperglycemia.
- To compare the hyperglycemic response to ethanol between two distinct mouse lines (LS/Ibg and SS/Ibg).
Main Methods:
- Administered ethanol to LS/Ibg and SS/Ibg mice.
- Conducted glucose tolerance tests.
- Utilized fasting, adrenalectomy, and adrenergic antagonists (dibenamine, propranolol).
- Performed intracerebroventricular injections of ethanol.
Main Results:
- LS/Ibg mice exhibited a greater ethanol-induced hyperglycemic response compared to SS/Ibg mice.
- This difference was specific to ethanol and not observed with pentobarbital or halothane.
- Fasting, adrenalectomy, and adrenergic antagonists abolished the hyperglycemic effect.
- Intracerebroventricular ethanol administration confirmed central nervous system mediation.
Conclusions:
- Ethanol-induced hyperglycemia is mediated by the central nervous system.
- Adrenergic pathways play a crucial role in this response.
- Mouse line differences in central nervous system ethanol sensitivity impact glucose regulation.