Effect of various disintegrants on the availability of directly compressed sulphadimidine tablets

Sulphadimidine tablets were prepared using 50% w/w of the following vehicles, Celutab, anhydrous lactose and Avicel. Various disintegrants 5% w/w were also incorporated e.g. Primojel, Veegum F, Amberlite, STA-Rx, Meprogat and Alginate YZ. It was found that the disintegration time of the various tablets containing different disintegrants was considerably decreased. The disintegrants increased also the dissolution rate of the various tablet formulations containing sulphadimidine by different extent. The variations in the dissolution rate among the various tablet formulations may be due to the difference in the nature of the disintegrants and their mechanism of action and possibly their interactions with the drug or the vehicle.