Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rifampin and pseudomembranous colitis.

R Fekety, R O'Connor, J Silva

    Reviews of Infectious Diseases
    |July 1, 1983
    PubMed
    Summary

    Clostridium difficile can cause colitis, especially in patients on rifampin. While rare, rifampin-resistant C. difficile strains have been linked to mild colitis, often treatable by stopping rifampin or using vancomycin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Jet energy measurement and its systematic uncertainty in proton-proton collisions at [Formula: see text] TeV with the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Hydration status and water sources in free-living physically active elderly.

    Nutricion hospitalaria·2015
    Same author

    ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for metastable heavy charged particles with large ionisation energy loss in <i>pp</i> collisions at [Formula: see text] TeV using the ATLAS experiment.

    The European physical journal. C, Particles and fields·2015
    Same author

    Study of the spin and parity of the Higgs boson in diboson decays with the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Two-particle Bose-Einstein correlations in <i>pp</i> collisions at [Formula: see text] 0.9 and 7 TeV measured with the ATLAS detector.

    The European physical journal. C, Particles and fields·2015

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Clostridium difficile is a common cause of antibiotic-associated colitis.
    • Most C. difficile isolates are susceptible to rifampin.
    • Rifampin-resistant C. difficile isolates have been linked to colitis in animal models and humans.

    Purpose of the Study:

    • To investigate the role of rifampin in C. difficile-associated colitis.
    • To analyze documented cases of rifampin-associated colitis in humans.

    Main Methods:

    • Review of documented human cases of C. difficile colitis associated with rifampin treatment.
    • Analysis of patient demographics, co-morbidities, and concomitant antimicrobial use.
    • Characterization of C. difficile isolate susceptibility to rifampin.

    Main Results:

    • Six cases of C. difficile colitis linked to rifampin were documented, primarily in elderly patients treated for tuberculosis.
    • These patients often had co-existing liver disease and received multiple antimicrobial agents.
    • The C. difficile isolate from one patient was resistant to rifampin.
    • Colitis was generally mild and responded to rifampin cessation or vancomycin treatment.

    Conclusions:

    • Rifampin is rarely implicated in C. difficile colitis, but resistant strains can cause disease.
    • Risk factors may include advanced age, liver disease, and concurrent antibiotic use.
    • Discontinuation of rifampin or vancomycin therapy are effective treatment options.

    Related Experiment Videos