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Related Experiment Videos

Hypoglycemic coma due to disopyramide toxicity.

J T Stapleton, M W Gillman

    Southern Medical Journal
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Disopyramide, an antiarrhythmic drug, can cause serious side effects like hypoglycemic coma and obstructive uropathy in elderly patients with diabetes and kidney issues.

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    Area of Science:

    • Pharmacology
    • Nephrology
    • Endocrinology

    Background:

    • Disopyramide is a commonly prescribed antiarrhythmic medication.
    • It is generally considered well-tolerated in most patient populations.

    Observation:

    • An 82-year-old patient with non-insulin-dependent diabetes mellitus and renal insufficiency was treated with disopyramide.
    • The patient presented with hypoglycemic coma and obstructive uropathy.

    Findings:

    • Disopyramide therapy was identified as the cause of both hypoglycemic coma and obstructive uropathy in this patient.
    • The patient's pre-existing conditions (diabetes and renal insufficiency) likely contributed to the adverse events.

    Implications:

    • This case highlights the potential for severe adverse drug reactions to disopyramide in elderly patients with comorbidities.

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  • Clinicians should exercise caution when prescribing disopyramide to patients with diabetes and renal impairment.
  • Monitoring for hypoglycemia and urinary tract complications is crucial in such individuals.