Poly-adenosine diphosphate ribose autoantibody in systemic lupus erythematosus and other related autoimmune diseases

The binding activities of poly-adenosine diphosphate-ribose (ADPR) and ds-DNA were measured in the sera of patients with systemic lupus erythematosus (SLE) and other collagen diseases in comparison with normal subjects. High polyADPR binding activity was detected in the SLE sera. The polyADPR binding assay was as sensitive as the DNA binding assay for diagnosing SLE. In SLE sera, the increased polyADPR binding activity was correlated with that of ds-DNA and negatively with the complement (CH50) titer. With improvement of clinical symptoms of SLE, the binding activity of polyADPR decreased in parallel to the binding activity of ds-DNA and opposite to the CH50 titer. The polyADPR binding activity was occasionally high in other collagen diseases. Effects of steroid treatment of SLE on the binding activities of polyADPR and ds-DNA, and CH50 titer were examined over half a year, indicating that both binding activities are reliable parameters for judgment of the clinical course.