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Related Experiment Videos

Serologically defined (SD) locus in cattle.

B Amorena, W H Stone

    Science (New York, N.Y.)
    |July 14, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified 11 bovine lymphocyte antigens (BoLA-A) using cytotoxic serums. These antigens, controlled by codominant alleles, confirm a major histocompatibility system in cattle.

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    Area of Science:

    • Immunogenetics
    • Veterinary Immunology

    Background:

    • The bovine immune system's complexity requires detailed characterization of its genetic components.
    • Understanding bovine lymphocyte antigens is crucial for immunology and animal breeding.

    Purpose of the Study:

    • To identify and characterize novel lymphocyte antigens in cattle.
    • To investigate the genetic control of these antigens.
    • To establish the presence of a major histocompatibility system in cattle.

    Main Methods:

    • Utilizing cytotoxic serums derived from multiparous cows.
    • Employing alloimmunization techniques to generate specific antibodies.
    • Serological typing to define lymphocyte antigens.

    Main Results:

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    • Detection of 11 distinct lymphocyte antigens.
    • Identification of codominant alleles controlling these antigens.
    • Designation of the BoLA-A locus for these antigens.

    Conclusions:

    • The identified antigens and their alleles define the BoLA-A locus.
    • The findings provide strong evidence for a major histocompatibility system in cattle.
    • This establishes a foundation for further immunogenetic studies in bovines.