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Updated: Aug 1, 2026
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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
Summary
A novel low-frequency red blood cell antigen, Hga, was identified. This antigen is inherited in an autosomal dominant pattern and appears to be rare in the population.
Area of Science:
- Immunology
- Genetics
- Hematology
Background:
- Routine antibody identification tests can reveal new blood group antigens.
- The Hga antigen was discovered serendipitously during such screening.
Purpose of the Study:
- To describe a newly identified low-frequency blood group antigen, Hga.
- To investigate the inheritance pattern and frequency of the Hga antigen.
Main Methods:
- Screening of group O donors for the Hga antigen.
- Family studies to determine inheritance patterns.
- Testing of sera for the presence of anti-Hga antibodies.
Main Results:
- The Hga antigen was found in 2 out of 5,434 group O donors, a frequency of 1:2717.
- Hga is inherited as a Mendelian autosomal dominant trait.
- Hga segregates independently of Rh, MNS, X, and Y.
- No anti-Hga antibodies were found in 6,580 sera.
Conclusions:
- Hga is a newly described low-frequency blood group antigen.
- Its autosomal dominant inheritance and independent segregation are established.
- The absence of detectable anti-Hga in the tested population suggests its rarity or low immunogenicity.
