[Psoriasis therapy with the aromatic retinoid Ro 10-9359 (Tigason)]

Area of Science:

• Dermatology
• Pharmacology

Context:

• Psoriasis is a chronic inflammatory skin condition affecting a significant population.
• Existing treatments for psoriasis have varying efficacy and side effect profiles.

Purpose:

• To evaluate the therapeutic efficacy and safety of aromatic retinoid Ro 10-9359 (Tigason) in patients with psoriasis.
• To assess the benefits of combining Tigason with photochemotherapy for psoriasis treatment.

Summary:

• A study involving 63 psoriatic patients treated with Tigason for up to 84 weeks demonstrated its therapeutic effectiveness across various psoriasis forms.
• Combination therapy with photochemotherapy resulted in more rapid healing compared to Tigason monotherapy.
• Adverse effects such as cheilitis, hair loss, and onycholysis were observed but resolved upon dose reduction, indicating manageable safety.

Impact:

• Tigason represents a valuable therapeutic option for managing diverse forms of psoriasis.
• The findings support the use of combination therapy for enhanced treatment outcomes in psoriasis.
• This study contributes to understanding the clinical utility and safety profile of aromatic retinoids in dermatological practice.