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Iodine kinetics in patients with euthyroid multinodular goitre compared with normal subjects
Acta Endocrinologica
|November 1, 1983
Summary
Euthyroid multinodular goitre patients do not have increased iodine loss via urinary excretion. Iodine handling in the thyroid gland is not significantly different in these patients compared to healthy individuals.
Area of Science:
- Endocrinology
- Nuclear Medicine
- Thyroid Research
Background:
- Euthyroid multinodular goitre (EMG) is a common thyroid condition.
- The role of iodine metabolism in EMG pathogenesis requires further clarification.
Purpose of the Study:
- To investigate iodine excretion and thyroid handling in patients with EMG.
- To determine if elevated renal clearance or altered thyroidal iodine handling contributes to iodine deficiency in EMG.
Main Methods:
- Compared thyroid clearance (TC), absolute iodine uptake (AIU), renal 123I clearance (RC), and plasma inorganic iodine (PII) in 33 EMG patients and 30 controls.
- Analyzed data based on age groups (≤50 and >50 years).
Main Results:
- EMG patients exhibited lower PII and higher TC compared to controls.
- Older controls (>50 years) showed higher PII and lower TC/RC, potentially due to increased iodine uptake.
- No significant differences in AIU were observed between EMG patients and controls.
Conclusions:
- Elevated renal iodine clearance is not a primary factor in endogenous iodine deficiency in sporadic goitre.
- Altered iodine handling in the thyroid gland does not appear to be a significant factor in EMG pathogenesis.
- Increased absolute iodine uptake was not observed in goitrous patients at the studied plasma iodine levels.