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Related Experiment Videos

Oxygen uptake and central circulation during ketamine anaesthesia.

L Tokics, B Brismar, G Hedenstierna

    Acta Anaesthesiologica Scandinavica
    |August 1, 1983
    PubMed
    Summary

    Ketamine anesthesia impacts cardiac output and oxygen uptake during abdominal surgery. While initial anesthesia decreases oxygen uptake, it returns to baseline during surgery, showing a link with cardiac output dynamics.

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    Area of Science:

    • Anesthesiology
    • Cardiovascular Physiology
    • Surgical Medicine

    Background:

    • Understanding the physiological effects of anesthetic agents is crucial for patient safety.
    • Ketamine anesthesia is used in various surgical settings, but its impact on hemodynamics and metabolism requires detailed study.

    Purpose of the Study:

    • To investigate the effects of ketamine anesthesia on cardiac output, oxygen uptake, and plasma catecholamines during upper abdominal surgery.
    • To explore the relationship between oxygen uptake and cardiac output under ketamine anesthesia.

    Main Methods:

    • Cardiac output was measured using the Fick principle.
    • Oxygen uptake was determined via mass spectrometry.
    • Plasma catecholamines (adrenaline and noradrenaline) were analyzed using high-performance liquid chromatography.

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    Main Results:

    • Ketamine anesthesia initially decreased stroke volume by 27% and increased heart rate, maintaining cardiac output. Oxygen uptake fell by 18% initially.
    • During surgery, cardiac output transiently decreased, while oxygen uptake returned to awake levels.
    • Plasma adrenaline levels decreased initially then normalized, whereas noradrenaline levels remained elevated throughout anesthesia.

    Conclusions:

    • A relationship exists between oxygen uptake and cardiac output during ketamine anesthesia, similar to other anesthetic techniques, excluding the initial hyperkinetic phase.
    • No direct correlation was found between plasma catecholamine concentrations and central hemodynamic changes during ketamine anesthesia.