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Related Experiment Videos

Dense microspheres in normal human brain.

P Averback

    Acta Neuropathologica
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    The dense microsphere (DMS) is a brain structure whose function remains unknown. Its frequency decreases with age but shows no significant difference across various neurological diseases, suggesting age-related changes rather than disease-specific alterations.

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    Area of Science:

    • Neuroscience
    • Neuropathology
    • Human Brain Anatomy

    Background:

    • The human brain contains a microscopical structure known as the dense microsphere (DMS).
    • The precise function and significance of DMS in the postinfancy brain are currently undetermined.
    • Previous research has not established a clear role for DMS in neurological conditions.

    Purpose of the Study:

    • To describe the light microscopical, topographical, histochemical, and ultrastructural features of DMS.
    • To investigate the frequency of DMS in the temporal neocortex across different neurological diseases and age groups.
    • To explore potential correlations between DMS presence and age or specific neuropathologies.

    Main Methods:

    • Microscopical analysis including light microscopy, histochemistry, and ultrastructural examination.

    Related Experiment Videos

  • Comparative frequency analysis of DMS in temporal neocortex samples from normal individuals and patients with Alzheimer's disease, Parkinson's disease, schizophrenia, and other nervous diseases.
  • Statistical comparison of DMS frequency based on diagnostic categories and age.

    • Main Results:

    • Detailed characterization of the light microscopical, topographical, histochemical, and ultrastructural properties of DMS.
    • No statistically significant differences in DMS frequency were observed between normal individuals and patients with Alzheimer's disease, Parkinson's disease, schizophrenia, or other nervous diseases.
    • A statistically significant reduction in the frequency of DMS was found with increasing age.

    Conclusions:

    • The study provides a comprehensive description of the dense microsphere (DMS) in the human brain.
    • DMS frequency is not significantly altered in common neurodegenerative diseases or psychiatric disorders studied.
    • Age-related decline in DMS frequency suggests a potential role in the aging process rather than in specific disease pathologies.