Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphological changes in bromocriptine-treated pituitary tumours.

M Anniko, J Wersäll

    Acta Oto-Laryngologica
    |September 1, 1983
    PubMed
    Summary

    Bromocriptine treatment of pituitary tumors showed varied morphological changes, but no consistent correlation to drug effectiveness was found in this study. Further research is needed to understand tumor response to bromocriptine.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hair cell damage in the inner ear of the Guinea pig due to noise in a workshop.

    Acta oto-laryngologica·2011
    Same author

    In vitro evaluation of the astatinated chimeric monoclonal antibody U36, a potential candidate for treatment of head and neck squamous cell carcinoma.

    European journal of nuclear medicine and molecular imaging·2005
    Same author

    Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue.

    International journal of oncology·2005
    Same author

    Hearing loss in relation to round window membrane morphology in experimental chronic otitis media.

    ORL; journal for oto-rhino-laryngology and its related specialties·2001
    Same author

    How can the hooded seal dive to a depth of 1000 m without rupturing its tympanic membrane? A morphological and functional study.

    Acta oto-laryngologica·2001
    Same author

    Localization of nitric oxide synthase isoforms in the human cochlea.

    Acta oto-laryngologica·2001

    Area of Science:

    • Endocrinology
    • Neurosurgery
    • Pathology

    Background:

    • Pituitary tumors are a significant clinical challenge.
    • Bromocriptine is a dopamine agonist used in treating certain pituitary tumors, particularly prolactinomas.
    • Pre-surgical bromocriptine treatment aims to reduce tumor size and hormonal secretion.

    Observation:

    • Eight patients with pituitary tumors (prolactinomas, GH-secreting, and mixed GH/PRL-secreting) received pre-surgical bromocriptine treatment.
    • Tumor tissue was analyzed using light and electron microscopy post-treatment.
    • Patients included in this analysis had shown no or unsatisfactory clinical/radiological response to bromocriptine therapy.

    Findings:

    • Significant morphological changes were observed in 4 cases, with minor changes in another 4.
    • Specific changes indicating a drug-induced dysfunction effect were noted in one case.
    • No consistent correlation was established between tumor susceptibility to bromocriptine and dose, duration of treatment, or tumor type.

    Implications:

    • The study highlights the variable morphological response of pituitary tumors to bromocriptine.
    • Predicting bromocriptine efficacy based on tumor type or treatment parameters remains challenging.
    • Further investigation is warranted to elucidate mechanisms of bromocriptine resistance and identify predictive biomarkers for treatment response in pituitary tumors.

    Related Experiment Videos