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Related Experiment Videos

Iohexol compared with metrizoate in urography.

K Levorstad, A Kolbenstvedt, E W Løyning

    Acta Radiologica: Diagnosis
    |January 1, 1983
    PubMed
    Summary

    The new non-ionic contrast medium iohexol (Omnipaque) resulted in fewer patient reactions and less tachycardia compared to the ionic medium metrizoate (Isopaque) during urography. Both contrast agents produced high-quality imaging results.

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    Area of Science:

    • Radiology
    • Medical Imaging
    • Pharmacology

    Background:

    • Urography is a common diagnostic procedure.
    • Contrast media are essential for urography.
    • Ionic contrast media have been associated with adverse reactions.

    Purpose of the Study:

    • To compare the safety and efficacy of a new non-ionic contrast medium, iohexol (Omnipaque), with a conventional ionic contrast medium, metrizoate (Isopaque).
    • To evaluate subjective patient reactions, hemodynamic effects, and image quality.

    Main Methods:

    • A randomized, double-blind comparison was conducted.
    • 20 patients received iohexol, and 22 patients received metrizoate.
    • Adverse reactions, tachycardia, blood pressure, and laboratory parameters were monitored.

    Main Results:

    • Iohexol (Omnipaque) caused significantly fewer subjective reactions and less tachycardia than metrizoate (Isopaque).
    • No significant differences were found in blood pressure, hematologic, or clinical chemical parameters.
    • Both contrast media yielded urographic films of similar, high quality.

    Conclusions:

    • Iohexol is a safer alternative to metrizoate for urography, with a reduced incidence of adverse effects.
    • The non-ionic contrast medium iohexol provides comparable image quality to the ionic contrast medium metrizoate.
    • Iohexol represents an advancement in contrast media for urographic procedures.

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