Pharmacokinetics of oxprenolol in the elderly

This paper is a brief review of the problems associated with drug therapy in the elderly. Although the elderly are more prone to suffer adverse reactions to drugs and to respond abnormally, impaired drug handling should not be blamed for these problems until other factors have been evaluated. Renal function deteriorates as people grow older, but the absorption, metabolism and distribution of most drugs may not be adversely affected by advancing age. Evidence to the contrary is sometimes based on studies of convalescent patients in whom an effect of disease or drug therapy cannot be excluded. For an assessment of the effects of aging on the pharmacokinetics of oxprenolol, 2 groups of 8 healthy females, mean age 21 and 68 years, respectively, were studied. Oxprenolol, 80 mg, was given orally in a single dose on day 1 and day 8 of a course of treatment; on the intervening days, oxprenolol, 80 mg, was given twice daily. The mean plasma concentration:time curves for both day 1 and day 8 for the 2 age groups were comparable. Thus, age alone does not affect the pharmacokinetics of oxprenolol.