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Disseminated infection by Aspergillus terreus
American Journal of Clinical Pathology
|November 1, 1983
Summary
A rare case of disseminated Aspergillus terreus infection occurred in an immunocompromised patient receiving chemotherapy for acute nonlymphocytic leukemia. Diagnosis involved lung biopsy identifying characteristic fungal elements, marking the first reported instance of this specific infection in such a host.
Area of Science:
- Mycology
- Infectious Diseases
- Hematology Oncology
Background:
- Acute nonlymphocytic leukemia (ANLL) is a hematologic malignancy often treated with intensive chemotherapy.
- Immunocompromised states significantly increase the risk of opportunistic infections, including invasive fungal infections.
- Disseminated aspergillosis is a serious complication in immunocompromised patients.
Observation:
- A patient with ANLL undergoing chemotherapy presented with pulmonary nodules.
- The patient subsequently developed central nervous system (CNS) symptoms.
- These clinical manifestations were suggestive of disseminated aspergillosis.
Findings:
- Open lung biopsy was performed for diagnosis.
- Fungal cultures from the biopsy identified Aspergillus terreus.
- Microscopic examination revealed conidia borne laterally along hyphae, characteristic of the Aspergillus terreus-flavipes group.
Implications:
- This case represents the first reported instance of disseminated Aspergillus terreus infection in an immunocompromised host.
- Highlights the importance of considering rare fungal pathogens in immunocompromised patients with atypical presentations.
- Emphasizes the diagnostic value of integrating clinical, radiological, and microbiological findings.