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Related Experiment Videos

Hyperprolactinemia. Long-term effects of bromocriptine.

D G Johnston, R W Prescott, P Kendall-Taylor

    The American Journal of Medicine
    |November 1, 1983
    PubMed
    Summary

    Long-term bromocriptine treatment effectively manages hyperprolactinemia, alleviating symptoms and reducing prolactin levels. While it induces tumor regression, hyperprolactinemia often recurs upon discontinuation, necessitating prolonged therapy.

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    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Pharmacology

    Background:

    • Hyperprolactinemia management includes surgery, irradiation, bromocriptine, or no treatment, with limited knowledge on long-term consequences.
    • The study evaluates long-term effects of bromocriptine or no treatment in 46 hyperprolactinemic patients over 12 months to six years.

    Purpose of the Study:

    • To assess the long-term clinical, biochemical, and radiological outcomes of bromocriptine treatment versus no treatment in hyperprolactinemia.
    • To evaluate the efficacy and safety of bromocriptine in managing hyperprolactinemia and associated pituitary tumors.

    Main Methods:

    • Clinical, biochemical, and radiological assessments were performed before and after treatment discontinuation in 46 hyperprolactinemic patients.
    • Patients included untreated individuals, those on bromocriptine (7.5-20 mg daily), and those with pituitary tumors.

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  • Seven patients were assessed before and after bromocriptine-induced pregnancies.

    • Main Results:

    • Bromocriptine treatment improved symptoms in all patients, with 67% symptom abolition, decreased prolactin levels in all, and normalization in 80%.
    • Radiological tumor regression was observed in patients with suprasellar and intrasellar adenomas, persisting throughout follow-up.
    • Upon discontinuation, prolactin levels remained lower but usually recurred; side effects were dose-related and troublesome in 13%.

    Conclusions:

    • Long-term bromocriptine therapy is highly effective for hyperprolactinemia, alleviating symptoms, suppressing prolactin, and inducing persistent tumor regression.
    • Treatment does not deteriorate other pituitary functions in patients with macroadenomas.
    • Hyperprolactinemia typically recurs after discontinuation, suggesting the need for prolonged treatment.