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Erythrocyte aggregation during normal pregnancy.

P Ozanne, O Linderkamp, F C Miller

    American Journal of Obstetrics and Gynecology
    |November 1, 1983
    PubMed
    Summary
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    Red blood cell aggregation increases during pregnancy, potentially raising thrombotic risk. This study confirms elevated aggregation in pregnant women, linked to higher fibrinogen levels.

    Area of Science:

    • Hematology
    • Physiology
    • Obstetrics

    Background:

    • Red blood cell aggregation, influenced by fibrinogen, impacts blood flow and thrombogenesis.
    • Pregnancy is associated with elevated fibrinogen and increased thrombotic event risk.

    Purpose of the Study:

    • To investigate changes in red blood cell aggregation during normal pregnancy.
    • To correlate red blood cell aggregation with plasma fibrinogen levels.

    Main Methods:

    • Utilized three in vitro assays: aggregation half time, zeta sedimentation ratio, and microscopic aggregation index.
    • Assessed red blood cell aggregation at 10, 25, 36 weeks of gestation, during labor, and in nonpregnant women.
    • Examined aggregation of Type O-positive red blood cells in plasma from pregnant and nonpregnant women.

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    Main Results:

    • Red blood cell aggregation was significantly increased throughout pregnancy compared to nonpregnant controls.
    • Plasma fibrinogen concentration strongly correlated with zeta sedimentation ratio and aggregation half time.
    • Increased aggregation was observed when red blood cells were suspended in plasma from pregnant women, indicating plasma-mediated effects.

    Conclusions:

    • Normal pregnancy is characterized by enhanced red blood cell aggregation.
    • Elevated plasma fibrinogen is a key factor contributing to increased red blood cell aggregation during pregnancy.
    • These findings suggest a potential mechanism for altered blood viscosity and increased thrombotic risk in pregnancy.