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Gentamicin-induced hypomagnesemia.

C K Finton, S Bjorkland, G P Zaloga

    The American Surgeon
    |November 1, 1983
    PubMed
    Summary
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    Gentamicin therapy can cause hypomagnesemia (low magnesium). This study in primates shows a direct link, with most animals developing low magnesium levels after 10 days of gentamicin treatment.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Case reports suggest a link between gentamicin and hypomagnesemia.
    • Establishing a direct cause-and-effect relationship is challenging due to confounding factors like high gentamicin doses, co-administered drugs, and inadequate monitoring.

    Purpose of the Study:

    • To establish a direct cause-and-effect relationship between gentamicin administration and hypomagnesemia.
    • To determine the frequency of gentamicin-induced hypomagnesemia.

    Main Methods:

    • Six healthy primates received gentamicin for 10 days.
    • Serum and urine magnesium levels were monitored throughout the study.

    Main Results:

    • Five out of six primates developed a significant decrease in serum magnesium levels (mean decrease of 0.34 mg/dl).

    Related Experiment Videos

  • Four primates exhibited frankly hypomagnesemic levels (below 1.4 mg/dl).
  • Inappropriately elevated urine magnesium excretion was observed relative to serum concentrations.

    • Conclusions:

    • Gentamicin-induced hypomagnesemia may be more common than previously recognized.
    • Serial monitoring of serum magnesium is recommended for patients receiving gentamicin therapy.