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Abstract:
Sensitivity of 129 strains of pathogenic staphylococci isolated from patients with pneumonia was studied with respect to a large number of drugs in the Bacteriological Laboratory of Konstantiny in the Algerian People's Democratic Republic. The method of paper discs and the Müller-Hinton solid nutrient medium were used. The staphylococcal strains were highly sensitive to cephalosporins, some of aminoglycosides (neomycin, gentamicin, tobramycin), nitrofurans, rifampicin, some antibiotics of other groups. Minocycline proved to be the most active among the tetracycline antibiotics. The number of the strains sensitive to it amounted to 82 per cent. 74--76 per cent of the isolates were resistant to tetracycline and oxytetracycline. 40--77 per cent of the isolates were resistant to sulfanilamides.
Insights
Pathogenic staphylococci causing pneumonia show high sensitivity to cephalosporins and minocycline. However, resistance to tetracyclines and sulfanilamides is significant, impacting treatment options.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Study conducted in the Algerian People's Democratic Republic.
- Focus on pathogenic staphylococci strains isolated from pneumonia patients.
- Utilized standard microbiological techniques (paper disc method, Müller-Hinton medium).
Purpose:
- To determine the antimicrobial susceptibility patterns of staphylococcal strains from pneumonia patients.
- To evaluate the efficacy of various antibiotic classes against these isolates.
- To identify effective therapeutic agents and highlight resistance trends.
Summary:
- 129 strains of pathogenic staphylococci were tested against numerous drugs.
- High sensitivity observed for cephalosporins, certain aminoglycosides (neomycin, gentamicin, tobramycin), nitrofurans, rifampicin, and minocycline.
- Minocycline demonstrated high activity (82% sensitivity), while tetracycline and oxytetracycline showed significant resistance (74-76%).
- Substantial resistance rates were also noted for sulfanilamides (40-77%).
Impact:
- Provides crucial data for guiding antibiotic therapy for staphylococcal pneumonia in the region.
- Highlights the need for ongoing surveillance of antimicrobial resistance.
- Informs empirical treatment strategies and antibiotic stewardship programs.