Related Experiment Video
Updated: Aug 9, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Efficacy of intravenous sotalol on ventricular arrhythmias occurring during maximal exercise stress testing
Abstract:
The efficacy and safety of an intravenous dose of 40 to 100 mg sotalol was evaluated in fourteen symptomatic patients with ventricular arrhythmias occurring during maximal exercise stress testing. A statistically significant reduction in premature ventricular complexes (PVC's) occurring as singles, doublets and triplets was observed during both exercise (p less than 0.05) and recovery (p less than 0.01). Sotalol plasma levels after administration of 100 mg i.v. ranged from 3.7 to 4.75 micrograms/ml (average 4.2 micrograms/ml). The injected dose was well tolerated in all patients. Neither arrhythmogenic nor adverse effects were observed.
More Related Videos
Related Concept Videos
Heart Failure Drugs: Inotropic Agents
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Dysrhythmias V: Evaluating Dysrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

