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Related Experiment Videos

Hand muscle atrophy in multiple sclerosis.

M Fisher, R R Long, D A Drachman

    Archives of Neurology
    |December 1, 1983
    PubMed
    Summary
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    Focal muscular atrophy is common in multiple sclerosis (MS), often due to disuse from central motor pathway damage, not just motor unit disease. This finding challenges previous assumptions about MS-related muscle loss.

    Area of Science:

    • Neurology
    • Neuroscience
    • Musculoskeletal Disorders

    Background:

    • Muscular atrophy in multiple sclerosis (MS) was historically considered rare and linked to motor unit diseases.
    • Previous understanding attributed MS-related muscle wasting primarily to direct involvement of the motor nervous system.

    Purpose of the Study:

    • To investigate the occurrence and potential causes of focal muscular atrophy in patients with multiple sclerosis.
    • To determine if muscular atrophy in MS is exclusively associated with motor unit pathology.

    Main Methods:

    • Reviewed nine patients with multiple sclerosis (MS) diagnosed with focal hand muscle atrophy and weakness.
    • Utilized strict diagnostic criteria to assess muscle atrophy and weakness.
    • Conducted electrodiagnostic tests to rule out anterior horn cell or axonal abnormalities.

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    Main Results:

    • Identified focal hand muscle atrophy and associated weakness in all nine MS patients.
    • Electrodiagnostic studies showed no evidence of anterior horn cell or axonal damage in these patients.
    • Findings suggest atrophy is common in MS and not solely due to motor unit disease.

    Conclusions:

    • Focal muscular atrophy is a frequent manifestation in multiple sclerosis (MS).
    • Relative disuse atrophy, resulting from damage to central motor control pathways, is a likely cause.
    • This challenges the classical view that MS-related muscle atrophy is exclusively due to motor unit involvement.