A systems model of schizophrenic dysfunction

A review of pertinent literature suggests that central integrative, as opposed to peripheral, systems are primarily at fault in schizophrenia. More specifically, it is proposed that the central decision apparatus, defined as the subsystems which determine goals and end-states, is intermittently dysfunctional. This dysfunction, in turn, leads to a decoupling of the negative feedback system which normally aligns responses with the desired goal. The failure of these central systems is accompanied by an increase of diffuse activity within neural systems, semiautonomous activity on the part of subsystems, and a partial failure to regulate arousal systems. The paper closes with suggestions for future research in schizophrenia.