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DMSO is a substrate for chloroperoxidase
Biochemical and Biophysical Research Communications
|October 14, 1983
Summary
Dimethyl sulfoxide (DMSO) is not inert in haloperoxidase reactions. It forms halosulfoxide, sulfone, and halosulfone, impacting biological significance.
Area of Science:
- Biochemistry
- Organic Chemistry
Background:
- Dimethyl sulfoxide (DMSO) is a common nonaqueous solvent used in enzymatic reactions.
- Haloperoxidases are enzymes that catalyze halogenation reactions.
Purpose of the Study:
- To investigate the reactivity of dimethyl sulfoxide under chloroperoxidase reaction conditions.
- To identify potential byproducts formed from DMSO during these reactions.
Main Methods:
- Chloroperoxidase-catalyzed reactions were performed using DMSO as a solvent.
- Reaction products were analyzed to identify any DMSO derivatives.
Main Results:
- Dimethyl sulfoxide was found to be reactive under chloroperoxidase conditions.
- Formation of halosulfoxide, sulfone, and halosulfone from DMSO was observed.
Conclusions:
- DMSO is not an inert solvent in chloroperoxidase-catalyzed reactions.
- The formation of these byproducts has potential biological implications that warrant further discussion.